|
KMID : 0857020020170010054
|
|
Kosin Medical Journal
2002 Volume.17 No. 1 p.54 ~ p.57
|
|
|
Serum Pepsinogens as a Predict of Stomach Cancer
|
|
Yoon Ki-Young
Lee Sang-Ho
Choi Kyung-Hyun
|
|
|
Abstract
|
|
|
Background : Human pepsinogens Ⅰ and Ⅱ, a precursor of pepsin, is secreted by the mucous neek and chief cells of fundic gland and antrium, previous reports suggest that a low serum level of pepsinogen Ⅰ, Ⅱ correlated well with the extent of premalignant lesions in the stomach, such as intestinal metaplasia and atrophic gastritis, and may act as a predictor of increased risk of gastric carcinoma. In previous studies, factors influencing the serum level of pepsinogen I have been thought to be only tumor histology.
Methods : The arm of the present study was to measure the serum levels of pepsinogen Ⅰ and Ⅱ and Ⅰ/Ⅱ ratio 74 patient with gastric cancer and another 30 healthy controls. The histological of gastric cancer was classified into diffuse and intestinal type in accordance with Lauren’s classification and early gastric cancer, advanced gastric cancer.
Result : The pepsinogen Ⅰ and Ⅱ levels among patients were higher and pepsinogen Ⅰ/Ⅱ ratio may be a useful screening test for gastric carcinoma. This impression should be confirmed by more extensive fields trial to determine.
|
|
|
KEYWORD
|
|
|
gastric carcinoma, serum pepsinogens
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|